Testosterone Propionate Injection USP

Composition:

Each ml contains: Testosterone Propionate USP 100 mg, Oil base q.s.

PHARMACOLOGICAL CLASSIFICATION:

Mechanism of Action
Testosterone Propionate: It is a highly anabolic as well as an androgenic steroid. It is a common oil-based injectable testosterone. The added propionate extends the activity of the testosterone but it is still comparatively much faster acting than other testosterone esters such as cypionate and enanthate. Propionate is most commonly injected at least every third day to keep blood levels steady. This drug is quite effective for strength and muscle mass gains. Propionate is often a very painful injection.

Clinical Pharmacology:

Endogenous androgen are responsible for the normal growth and development of the male sex organs and for the maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis and scrotum, development of male hair distribution such as beard, pubic, chest and axillary hair, laryngeal enlargement, vocal chord thickening, alterations in body musculature and fat distribution.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase, thus testosterone enanthate can be given at intervals of two to four weeks. Testosterone in plasma is 98% bound to specific testosterone estradiol-binding globulin and about 2 % is free. The free testosterone concentration will determine its half-life. About 90% of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites and about 6 % of a dose is excreted in the feces, mostly in the unconjugated form.

INDICATIONS:

Testosterone propionate is a commonly manufactured, oil-based injectable testosterone compound. The added propionate ester will slow the rate in which the steroid is released from the injection site, but only for a few days. Testosterone propionate is therefore comparatively much faster acting than other testosterone esters such as cypionate or enanthate and requires a much more frequent dosing schedule. While cypionate and enanthate are injected on a weekly basis, propionate is generally administered (at least) every third day. Figure one illustrates a typical release pattern after injection. As you can see, levels peak and begin declining quickly with this ester of testosterone.
To make Testosterone Propionate even more uncomfortable to use, the propionate ester can be very irritating to the site of injection. In fact, many sensitive individuals choose to stay away from Testosterone Propionate completely, their body reacting with a pronounced soreness and low-grade fever that may last for a few days. Even the mild soreness that is experienced by most users can be quite uncomfortable, especially when taking multiple injections each week. Standard esters like enanthate and cypionate, which are clearly easier to use, are therefore much more popular among athletes.

Those who are not bothered by frequent injections will find that propionate is quite an effective steroid. It is of course of a powerful mass drug, capable of producing rapid gains in size and strength. At the same time, the buildup of estrogen and DHT (dihydrotestosterone) will be pronounced, so typical testosterone side effects are to be expected. Some do consider Testosterone Propionate to be the mildest testosterone ester, and the preferred form of this hormone for dieting/cutting phases of training. Some will go so far as to say that propionate will harden the physique. while giving the user less water and fat retention than one typically expects to see with testosterone. Realistically, however, this is nonsense. The ester is removed before testosterone is active in the body, and likewise, the ester cannot alter the activity of the parent steroid in any way, only slow its release. We can say that propionate might be the favored testosterone among female bodybuilders (for those who insist on testosterone use!) as blood levels are easier to control with it compared to other esters. Should virilization symptoms develop, one would not wish to wait the weeks needed for testosterone concentrations to fall after a shot of enanthate for example.

CONTRA-INDICATIONS:

Androgens are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate and in women who are or may become pregnant.

DOSAGE AND DIRECTIONS FOR USE:

The most common dosage schedule for Testosterone Propionate (men) is to inject 50 to 100 mg, every 2nd or 3rd day. As with the more popular esters, the total weekly dosage would be in the range of 200-400 mg. As with all testosterone compounds, this drug is most appropriately suited for bulking phases of training. Women who absolutely must use injectable testosterone should only use this preparation. The Testosterone Propionate dosage schedule should also be more spread out for a female bodybuilder, with injections coming every 5 to 7 days. The dosage obviously would be lower as well, generally in the range of 25 mg to 50 mg per injection. Androgenic activity should be less pronounced with this schedule, giving blood levels time to sufficiently decrease before the drug is administered again. In order to further reduce any risks, the duration of this cycle should not exceed 8 weeks. Should a stronger anabolic effect be needed, a small amount of Duramin (Deca-Duralin if unavailable), Oxandrolone or Winstrol could be added. Of course, the risk of noticing virilizing effects from these drugs may increase, even with the addition of a mild anabolic. Since many of the masculinizing side effects of steroid use can be irreversible, it is very important for the female athlete to monitor the dosage, duration, and incidence of side effects very closely.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:

Nausea, vomiting, headache, skin color changes, increased/decreased sexual interest, oily skin, hair loss, and acne may occur. Pain and redness at the injection site may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects when it is used at normal doses. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as anxiety, depression, increased anger), trouble sleeping/snoring, signs of serious liver disease (such as persistent abdominal pain/nausea, unusual tiredness, yellowing eyes/skin, dark urine), hands/ankles/feet swelling, unusual tiredness, fast/irregular heartbeat.

OVERDOSAGE :

If you take too much testosterone, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If testosterone is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

STORAGE: Store below 30°C. Protect from light.